This content is very useful especially when you are trying to play as a mid laner. Basically everyone knows that runes can be useful in many aspects of Dota. It helps you get the advantage needed to increase your chances of winning the game.
The runes spawn randomly by the start of the game (first creep spawn) and every 2 minutes a new rune will be up.
0:00, 2:00, 4:00, 8,:00, 10:00, 12:00, 14:00, 16, 18:00 and so on...